The Binding of Isaac: Four Souls*
The official multiplayer card game inspired by the hit video game features themes of sacrifice, betrayal, and hoarding. Players alternate playing loot cards and using items to defeat monsters, which can yield additional items, loot, and sometimes souls. The first player to finish their turn with four souls wins the game, and cooperation, trading, and betrayal are encouraged.
- 2 - 4 Players
- 30 - 60 Minutes
- 13+ years old
- Easy to learn
We like The Binding of Isaac: Four Souls so much that we recommend it in the following board game recommendation lists 2025
- Position 8 in The best games where players can form alliances
- Position 15 in The best games where you can make agreements with other players
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